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Sample Preparation

Sample Preparation

Dr. David A. Wells is a recognized expert in sample preparation for drugs and chemicals, and is an established educator and author as a result of years of consulting within the pharmaceutical industry (since 1999). Dr. Wells formed Sample Prep Solutions Company to provide educational and technical support services that help pharmaceutical and biotech laboratory
service2professionals improve sample prep productivity. David was with 3M for 12 years in various R&D positions in drug metabolism, bioanalytical chemistry, product development and technical service, upon which he has built the expertise he now shares with colleagues.

For four years at 3M Pharmaceuticals, David investigated the metabolism and disposition of the novel antiviral immunomodulator drug imiquimod (Aldara®) in animals and man. Then he joined the company’s entrepreneurial effort in the 3M New Products Department to develop sample preparation products based on a novel membrane technology in which chromatographic particles are enmeshed within a network of PTFE fibrils. This project resulted in the manufacture and sale of 3M Empore® Extraction Products, including 96-well disk plates and extraction disk cartridges used for drug sample preparation with automated workstations. Over an 8-year period he helped develop, commercialize and support the Empore technology into a successful business and managed all Technical Service activities for the program.

Dr. Wells has developed productive working relationships with key opinion leaders and influential scientists at pharmaceutical companies, contract research laboratories, and manufacturers of sample preparation products and analytical equipment. Clients have included Johnson & Johnson, DuPont, Purdue Pharma, Bristol-Myers, Cedra Laboratories, Biovail, Quest Pharmaceutical Services, and many more companies.

Sample Prep Solutions provides education and training in bioanalytical drug sample preparation for LC-MS/MS analysis using high-throughput, automated techniques.


Hands-On Training

  1. Bioanalytical method development and optimizationservicelist
  2. Automation of existing methods
  3. High throughput sample preparation techniques
    • Solid-phase extraction
    • Protein precipitation
    • Liquid-liquid extraction

Educational Workshops

  1. Tailored to meet specific needs

Technical Writingr3

  1. Preparation of manuscripts and presentation materials


  1. Product development
  2. Research support in solving analytical challenges
  3. Development of new sample prep technologies or products

664521David wrote the first—and still the most highly regarded—authoritative reference book on drug sample preparation, High Throughput Bioanalytical Sample Preparation: Methods and Automation Strategies, published by Elsevier Science (2003). He has written manybook chapters and articles on sample preparation and analytical methods. Dr. Wells also contributes chapters to textbooks in analytical chemistry and drug discovery.

Wells DA. High Throughput Bioanalytical Sample Preparation: Methods and Automation Strategies. Amsterdam: Elsevier; 2003. Progress in Pharmaceutical and Biomedical Analysis; vol. 5. ISBN 0-444-51029-X (hardbound), ISBN 978-0-444-51029-7 (online), 628 pages.

Wells DA. Classical Solid-Phase Extraction. In: Wilson ID, Cooke M, Poole CF, eds. Encyclopedia of Separation Science. London: Academic Press; 2000: 4135-4141. ISBN 0-12-226770-2 (Ten Volume Set).

Wells DA. Bioanalytical Solid-Phase Extraction. In: Wilson ID, Cooke M, Poole CF, eds. Encyclopedia of Separation Science. London: Academic Press; 2000: 2142-2146. ISBN 0-12-226770-2 (Ten Volume Set).

Wells DA, Lloyd TL. Automation of Sample Preparation for Pharmaceutical and Clinical Analysis. In: Pawliszyn J, ed. Sampling and Sample Preparation for Field and Laboratory. Amsterdam: Elsevier; 2002: 837-868. Comprehensive Analytical Chemistry: Sampling and Sample Preparation for Field and Laboratory; vol 37. ISBN 0-444-50510-5 (hardbound), 0-444-50511-3 (paperback), 978-0-444-50510-1 (online), 1160 pages.

Wells DA. Sample Preparation for Drug Discovery Bioanalysis. In: Lee MS, ed. Integrated Strategies for Drug Discovery Using Mass Spectrometry. Hoboken, New Jersey: Wiley-Interscience; 2005: 477-510, doi:10.1002/0471721034.ch17. ISBN 0-471-46127-X (hardbound), 568 pages.

Wells DA. 2.28 – LC Automation. In: Pawliszyn J, ed. Comprehensive Sampling and Sample Preparation: Analytical Techniques for Scientists. Volume 2. Amsterdam, The Netherlands: Academic Press; 2012:613-648. Print ISBN: 978-0-12-381373-2; Electronic ISBN: 978-0-12-381374-9; 3,200 pages in 4 Volumes.

Wells DA. Sample preparation for mass spectrometry applications. In: Rifai N, Horvath R, and Wittwer C, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Sixth edition. Philadelphia, Pennsylvania: W.B. Saunders; 2017. Print ISBN 978-0-32-335921-4; eBook ISBN 978-0-32-354850-2 and 978-0-32-347351-4; 1,888 pages.

Maximizing Laboratory Productivity

Dr. Wells and his network of associates can help your laboratory maximize productivity in the following ways.

Filling Knowledge and Resource Gaps

Sample Prep Solutions fills the knowledge and resource gaps that may exist in your laboratory by working side-by-side with lab personnel on their own projects. Time is not lost in meeting project development goals; instead, an experienced scientist guides and trains your staff in method development and transfer to automation. Productivity and educational goals are achieved simultaneously while hands-on transfer of essential knowledge improves the expertise of your staff.

Implementing 96-Well Techniques

Sample prep techniques in the pharmaceutical industry have moved to a high throughput 96-well plate environment. Sample Prep Solutions introduces you to these applications and directs you to the products you need in a short time. Advanced training on automating method development and routine sample processing using this microplate format is a specialty.

The Advantage of Objectivity

Extensive experience in bioanalytical sample preparation makes Sample Prep Solutions an ideal single resource for technical service support on all sample preparation products. As an independent consultant, our unbiased expertise can help your laboratory select products and technologies that will meet your specific needs and provide optimal productivity.

Your Personal Mentor

t6From product selection to mentoring method development projects and data interpretation…from educational workshops on solid-phase extraction principles to hands-on training… Sample Prep Solutions provides unique professional services to bioanalytical laboratories to improve expertise and productivity in sample preparation techniques.



© 2019 David Wells, PHD. ALL RIGHTS RESERVED.